Role of IRF4-Mediated Inflammation: Implication in Neurodegenerative Diseases
نویسندگان
چکیده
منابع مشابه
Role of IRF4-Mediated Inflammation: Implication in Neurodegenerative Diseases
Neuro-inflammation is a common feature of various central nervous system (CNS) disorders, including stroke, Alzheimer’s disease, Multiple sclerosis, etc., and has a significant impact on the outcomes. Regulation of the immune response has therapeutic value. Interferon regulatory factor 4 (IRF4) is a hemopoietic transcription factor critical for activation of microglia/macrophages and modulation...
متن کاملRole of inflammation in neurodegenerative diseases.
PURPOSE OF REVIEW Inflammation is a self-defensive reaction aimed at eliminating or neutralizing injurious stimuli, and restoring tissue integrity. In neurodegenerative diseases inflammation occurs as a local response driven by microglia, in the absence of leucocyte infiltration. Like peripheral inflammation, neuroinflammation may become a harmful process, and it is now widely accepted that it ...
متن کاملP162: Emerging Perspectives on Mtor-Associated Inflammation in Neurodegenerative Diseases
Inflammatory processes have been shown to be involved in development and progression of neurodegenerative diseases. Mammalian target of rapamycin (mTOR) involves in various cellular processes including autophagy, apoptosis and energy metabolism. Recently, studies have been shown an association between mTOR pathway and inflammation, supporting the role of the pathway in the pathogenesis of infla...
متن کاملTherapeutic implication of autophagy in neurodegenerative diseases
Autophagy, a catabolic process necessary for the maintenance of intracellular homeostasis, has recently been the focus of numerous human diseases and conditions, such as aging, cancer, development, immunity, longevity, and neurodegeneration. However, the continued presence of autophagy is essential for cell survival and dysfunctional autophagy is thought to speed up the progression of neurodege...
متن کاملInflammation and neurodegenerative diseases.
The decline in mental fitness associated with Alzheimer disease is accompanied by physical changes in the brain, including the development of characteristic plaques and neurofibrillary tangles, but the pathogenesis of those changes is not clear. Recent work suggests that the activation of microglia in response to injury, illness, aging, or other causes begins a cascade of events that can best b...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neurology & Neurotherapy Open Access Journal
سال: 2017
ISSN: 2639-2178
DOI: 10.23880/nnoaj-16000107